Endocrine Abstracts

Tracheomalasia is extremely rare condition in Graves’ disease and may result in pneumomediastium with fistular formation from longstanding compression by a large goiter. There is no report that Graves’ disease combined with tracheomalasia and pneumomediastinum. A 24-year-old woman presented with abdominal pain, diarrhea and fever. On physical examination, a large goiter was detected on her anterior neck. Computed tomography of chest showed large amount of air in ante...

IntroductionAntithyroid drugs are widely used in the therapy of hyperthyroidism. This review (update of Cochrane review: Antithyroid drug regimen for treating Graves' hyperthyroidism. In: The Cochrane Library, Issue 4, 2003; with 4 additional trials) assesses the effects of dose, regimen and duration of antithyroid drug therapy for Graves' hyperthyroidism.MethodsThe Cochrane Controlled Trials Register, MEDLIN...

While iodine deficiency goitre is common worldwide, it is rarely described in the U.K. Vegan diet is the only real way for this deficiency to occur in the U.K. A MEDLINE search from 1966 revealed 1 reported case (Shaikh et al. Transient neonatal hypothyroidism due to a maternal vegan diet; Journal of Pediatric Endocrinology & Metabolism Jan 2003). We have identified 3 cases, which we will describe here.Case 1A 21-year-ol...

Adrenal masses are common incidental radiological findings. It has been estimated that as many as 10–20% of patients with essential hypertension may suffer from undiagnosed primary aldosteronism (PA). In patients who have both adrenal incidentaloma, which the functioning one must be identified. We report a case where an unilateral PA was detected on 18F-fluorodexoyglucose (FDG)-positron emission tomography (PET), and comfirmed by adrenal venous sampling.<p ...

Backgroud: The association with daily calcium intake and sarcopenia has not been well established.Objective: The objective was to assess the associate of daily calcium intake and sarcopenia.Methods: We analysed the fourth Korea National Health and Nutrition Examination Survey (KNHANES) in old adult (over 50 years), conducted in 2009. A total of 1964 non-obese (body mass index (BMI) <25 kg/m2) old adults (871 men and ...

Background: True cyclical Cushing's syndrome is rare and usually due to an ACTH-secreting corticotrophinoma. We describe a man with cyclical Cushing's syndrome of 15 years duration who had unexpected pituitary immunohistopathology.Clinical details: A 22-year-old man presented in 1986 with clinical features of Cushing's syndrome & urinary free cortisols up to 1800 nmol/24h, but normal low-dose DXM suppression, & normal pituitary and adrenals on CT. He was then lost ...

Background: Since receiving its UK licence in 1994, cabergoline [CAB] has become the dopamine agonist of choice for the management of hyperprolactinaemia in most UK endocrine units. Aim: To review the outcomes for the mother and neonate when CAB is taken during conception and into early gestation. Method: Retrospective review of Aberdeen casenotes from all hyperprolactinaemic women of childbearing age on CAB therapy and those of their live born infants. Results: Twenty women w...

Efficacy and Safety of High Dose Testosterone Therapy in Partial Androgen InsensitivityS. Bandyopadhyay, W.A.Watson, C. M.Park, P. Abraham, S. Philip, S. Acharya , J.S. Bevan. Department of Endocrinology, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZN.INTRODUCTION: There have been few reports of the efficacy and safety of high dose androgen therapy in men with partial androgen insensitivity (PAI). We report on the responses of a p...

The high survival rate for patients with differentiated thyroid carcinoma (DTC) declines markedly in those with bony metastases. We compare the management of two patients with large dominant pelvic metastases.Case 1 63 year old man with R hip pain. Investigation revealed a 10cm lesion in the R hemi pelvis and subsequent imaging and biopsy revealed a 9th rib lesion and metastatic follicular DTC. He underwent 131 I ablation of the normal thyroi...

Aims: Nonalcoholic fatty liver disease (NAFLD) is reported to contribute to the development of type 2 diabetes, but it is largely unknown whether such a relationship between NAFLD and incident diabetes relates to the severity of NAFLD or it is independent. We aimed to evaluate the association of the severity of NAFLD with development of type 2 diabetes in a retrospective cohort of Korean subjects.Methods: This study included 7,849 individuals without dia...